What is MOTS-c? MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA from the 12S rRNA region. Discovered in 2015, it represents a unique class of molecules that can translocate to the nucleus under stress conditions to regulate gene expression. Key characteristics: Encoded by mitochondrial DNA, not nuclear DNA Declines with age (21% reduction in …

Introduction: A Revolutionary Advance in Obesity Treatment Obesity has become a global health challenge. It is projected that by 2035, nearly a quarter of the world’s population will be affected by obesity. However, a groundbreaking study published in The New England Journal of Medicine (NEJM) brings exciting news for obesity treatment—the triple-hormone receptor agonist Retatrutide …